February 2, 2024

Excellence Strategy (ExStra) – SCALE continues to final stage of competition

The SCALE consortium is officially invited to submit the full proposal for the Excellence Strategy (ExStra) and with it reaches the final stage of the competition. The SCALE draft proposal was one ...

December 14, 2023

Kathi Zarnack und Achilleas Frangakis für SCALE im UniReport

In der aktuellen Ausgabe des UniReports wird die Themenreihe über die vier neuen Exzellenzinitiativen und das bereits bestehende Exzellenzcluster der Goethe Universität Frankfurt fortgesetzt. Dar...

December 5, 2023

Michaela Müller-McNicoll appointed as Max Planck Fellow

Michaela Müller-McNicoll, Spokesperson of SCALE, will become Max Planck Fellow at the Max Planck Institute (MPI) of Biophysics. As a Max Planck Fellow she will head a research group at the MPI for...

December 1, 2023

Inga Hänelt is Scientist of the Year 2023

Inga Hänelt, Spokesperson of SCALE, received this year’s “Scientist of the Year” award from the Alfons und Gertrud Kassel-Stiftung for her outstanding research on bacterial membr...

We are on X (Twitter)

(1/8) I am thrilled to share the latest work from
@BisLightyear @iamamardeeep
from @_KevinCorbett @EKimlab!

We show that the bacterial SMC Wadjet complex cleaves plasmid DNA through loop extrusion.

How does the #kidney filter 1500 liters of blood every day without loosing proteins?
Our #cryoET data of kidney tissue by #waffleMethod show that the slit diaphragm, which links #podocytes in the #glomeruli, looks like a fishnet!

Interesting perspective in @CellCellPress on the future of structural #cellbiology by @Beck_Laboratory, @CovinoLab, @IHanelt & @mixmue #BPS2024

Featured content from last week's #StructuralBiology anniversary focus issue: "Understanding the cell: Future views of structural biology"

Read the Perspective:

Martin Beck @MPIbp, @CovinoLab @fias_science, @goetheuni @IHanelt & Michaela Mueller-McNicoll

Check out our opinion piece "Understanding the cell: Future views of structural biology" now out in Cell. The future of structural and cellular biology is digital. Many thanks to @IHanelt @Beck_Laboratory and @mixmue for the great fun and discussions writing it

How can genetic perturbation of a central scaffolding component of the #nuclearpore result in a tissue specific defect? Work by @Reiya_Tan1guch1 and others in collaboration with @DoyeValerie makes this more conceivable (@MPIbp @IJMonod):

Intriguing perspective in @CellCellPress on the future of structural #cellbiology by our faculty members @Beck_Laboratory, @CovinoLab, @IHanelt and @mixmue, elaborating on novel technologies and the role of #AI towards understanding cellular functions!

Digital twins: the path to new discoveries in cells. FIAS researchers are playing a leading role in developing pioneering technology that will enter the next funding round as part of the SCALE excellence initiative. More here:

#poxvirus structure revealed by @Jiasui_Liu from B. Turonova's group & coworkers using #cryoET, subtomogram averaging & #alphafold. They uncovered the A10 trimer being the main component of the palisade layer, probably fulfilling functions during viral assembly and disassembly.

Figure shows #MDsimulations of complex cellular systems and is taken from:
M. Beck,R. Covino,I. Hänelt,M. Müller-McNicoll; "Understanding the cell: Future views of structural biology", Cell 187, 2024.
© 2023 The Authors. Published by Elsevier Inc.

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