The SCALE Science Lunch Seminar continues on Wednesday, May 27, 2026, at 12:30 h (s.t.) with a talk by Melike Lakadamyali Ph.D. (Department of Physiology, University of Pennsylvania).

Super-resolution imaging of chromatin in health and disease

Abstract
Super-resolution microscopy has opened new possibilities for visualizing chromatin architecture in situ at nanoscale resolution. Leveraging quantitative super-resolution imaging, we revealed the heterogeneous nature of nucleosome folding and demonstrated that chromatin structure at both nano- and meso-scales is highly plastic, dynamically remodeling in response to chemical and mechanical cues in health and disease. By combining biologically interpretable feature extraction with machine learning, we further showed that cells can be accurately classified into distinct states based solely on their multi-scale chromatin organization, while also identifying the specific chromatin features that drive classification, thus offering mechanistic insight into cell-state regulation.

The SCALE Science Lunch Seminar will take place in hybrid format. We warmly invite you to join us in person at the MPI for Biophysics, where a light lunch and coffee will be provided after the seminar. The talk will also be streamed live via Zoom. The zoom link will be sent by e-mail to the SCALE mailing list. To subscribe to the mailing list, please send an e-mail to scale-office@uni-frankfurt.de.

We look forward to welcoming you to the next SCALE Science Lunch Seminar.